Project paper on Addison Disease Research Example | Topics and Well Written Essays - 750 words

Project on Addison Disease - Research Paper Example so leads to the secretion of androgens which are important for the normal sexual development in a person along with the proper hair distribution (GANONG, 2005). In Addison’s Disease the hormone that is initially and mainly affected is aldosterone. It is then that cortisol and the androgens follow. The laboratory findings indicate the ionic imbalance led to by aldosterone deficiency. The decreased levels of sodium arise because the ions cannot be reabsorbed due to the absence of aldosterone and hence they are lost in urine which results in low levels of the sodium ions in the blood. At the same time potassium ions which are exchanged for sodium in the kidney tubules with the assistance of this hormone do not get excreted and this results in high levels of potassium in the blood and hence the condition hyperkalemia. The retention of hydrogen ions also occurs because aldosterone plays a role in the excretion of hydrogen ions. Thus this results in increased levels of hydrogen ions and resultant acidosis. Retention of chloride cannot occur due to decreased aldosterone as well which results in low levels of chloride ions in the blood. Anot her reason for low chloride level is that there is an exchange of chloride with the bicarbonate in the cells. This is because bicarbonate is required for the compensation of the acidosis which has resulted and hence the chloride ions enter the cell and the bicarbonate ions are ejected in the extracellular compartment. The loss of chloride ions can also be associated with the vomiting episodes that the patient had. This is because the gastric juices contain a high content of chloride and prolonged vomiting can lead to a reduction in the level of the chloride ions. The low level of carbon dioxide is also because of the compensatory hyperventilation which results to overcome the metabolic acidosis. This occurs in the form of deep breaths and is referred to as Kussmaul breathing. This results in loss of carbon dioxide and hence the